A Proof of Principle Study of the Terminal Sterilization of Prefilled Syringes Using A Water Cascade Process

• Main Authors: Drost-Wijnne Anne J.A (Author), Van Wezel Ralph A.C (Author), Deenen Maarten J. (Author), Van Doornmalen Gomez Hoyos Joost P.C.M (Author), Grouls René J.E (Author)
• Format: Book
• Published: De Gruyter, 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A new development in drug compounding is the production of ready-to-administer sterilized prefilled syringes. A challenge with these syringes is the method of terminal sterilization. There is no information available whether water cascade sterilization is a suitable method. We investigated the effec...