Enhanced cytotoxicity of a Pseudomonas Exotoxin A based immunotoxin against prostate cancer by addition of the endosomal escape enhancer SO1861

• Hoofdauteurs: Anie P. Masilamani (Auteur), Nathalie Huber (Auteur), Constanze Nagl (Auteur), Viviane Dettmer-Monaco (Auteur), Gianni Monaco (Auteur), Isis Wolf (Auteur), Susanne Schultze-Seemann (Auteur), Sanaz Taromi (Auteur), Christian Gratzke (Auteur), Hendrik Fuchs (Auteur), Philipp Wolf (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2023-07-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Immunotoxins consist of an antibody or antibody fragment that binds to a specific cell surface structure and a cytotoxic domain that kills the cell after cytosolic uptake. Pseudomonas Exotoxin A (PE) based immunotoxins directed against a variety of tumor entities have successfully entered the clinic...