Enhanced cytotoxicity of a Pseudomonas Exotoxin A based immunotoxin against prostate cancer by addition of the endosomal escape enhancer SO1861

• Main Authors: Anie P. Masilamani (Author), Nathalie Huber (Author), Constanze Nagl (Author), Viviane Dettmer-Monaco (Author), Gianni Monaco (Author), Isis Wolf (Author), Susanne Schultze-Seemann (Author), Sanaz Taromi (Author), Christian Gratzke (Author), Hendrik Fuchs (Author), Philipp Wolf (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Immunotoxins consist of an antibody or antibody fragment that binds to a specific cell surface structure and a cytotoxic domain that kills the cell after cytosolic uptake. Pseudomonas Exotoxin A (PE) based immunotoxins directed against a variety of tumor entities have successfully entered the clinic...