Synthesis and Preliminary Evaluation of an ASGPr-Targeted Polycationic <i>β</i>-Cyclodextrin Carrier for Nucleosides and Nucleotides

Most antiviral and anticancer nucleosides are prodrugs that require stepwise phosphorylation to their triphosphate nucleotide form for biological activity. Monophosphorylation may be rate-limiting, and the nucleotides may be unstable and poorly internalized by target cells. Effective targeting and d...

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Main Authors: Jang-Ha Ryu (Author), Weizhong Zheng (Author), Xiao-Hong Yang (Author), Hassan Elsaidi (Author), Jim Diakur (Author), Leonard I. Wiebe (Author)
Format: Book
Published: MDPI AG, 2024-02-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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