Synthesis and Preliminary Evaluation of an ASGPr-Targeted Polycationic <i>β</i>-Cyclodextrin Carrier for Nucleosides and Nucleotides
Most antiviral and anticancer nucleosides are prodrugs that require stepwise phosphorylation to their triphosphate nucleotide form for biological activity. Monophosphorylation may be rate-limiting, and the nucleotides may be unstable and poorly internalized by target cells. Effective targeting and d...
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Format: | Book |
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MDPI AG,
2024-02-01T00:00:00Z.
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A1234.567 |
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