Rational optimization of a monoclonal antibody improves the aggregation propensity and enhances the CMC properties along the entire pharmaceutical process chain

• Автори: Joschka Bauer (Автор), Sven Mathias (Автор), Sebastian Kube (Автор), Kerstin Otte (Автор), Patrick Garidel (Автор), Martin Gamer (Автор), Michaela Blech (Автор), Simon Fischer (Автор), Anne R Karow-Zwick (Автор)
• Формат: Книга
• Опубліковано: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

The discovery of therapeutic monoclonal antibodies (mAbs) primarily focuses on their biological activity favoring the selection of highly potent drug candidates. These candidates, however, may have physical or chemical attributes that lead to unfavorable chemistry, manufacturing, and control (CMC) p...