Costunolide covalently targets NACHT domain of NLRP3 to inhibit inflammasome activation and alleviate NLRP3-driven inflammatory diseases

• Main Authors: Haowen Xu (Author), Jiahao Chen (Author), Pan Chen (Author), Weifeng Li (Author), Jingjing Shao (Author), Shanshan Hong (Author), Yi Wang (Author), Lingfeng Chen (Author), Wu Luo (Author), Guang Liang (Author)
• Format: Book
• Published: Elsevier, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The NLRP3 inflammasome's core and most specific protein, NLRP3, has a variety of functions in inflammation-driven diseases. Costunolide (COS) is the major active ingredient of the traditional Chinese medicinal herb Saussurea lappa and has anti-inflammatory activity, but the principal mechanism...