Oxidative-Stress-Associated Proteostasis Disturbances and Increased DNA Damage in the Hippocampal Granule Cells of the Ts65Dn Model of Down Syndrome

• Main Authors: Alba Puente-Bedia (Author), María T. Berciano (Author), Carmen Martínez-Cué (Author), Miguel Lafarga (Author), Noemí Rueda (Author)
• Format: Knjiga
• Izdano: MDPI AG, 2022-12-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Oxidative stress (OS) is one of the neuropathological mechanisms responsible for the deficits in cognition and neuronal function in Down syndrome (DS). The Ts65Dn (TS) mouse replicates multiple DS phenotypes including hippocampal-dependent learning and memory deficits and similar brain oxidative sta...