Inflammatory-Dependent Bidirectional Effect of Bile Acids on NLRP3 Inflammasome and Its Role in Ameliorating CPT-11-Induced Colitis

• Autores principales: Chuyao Liao (Autor), Di Wang (Autor), Siyuan Qin (Autor), Ying Zhang (Autor), Jie Chen (Autor), Ruijie Xu (Autor), Fengguo Xu (Autor), Pei Zhang (Autor)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Irinotecan (CPT-11) in combination with 5-fluorouracil and leucovorin is a first-line chemotherapy regimen for the treatment of colorectal cancer; however, its clinical application is limited by the dose-limiting gastrointestinal toxicity of colitis. In our previous studies, several bile acids (BAs)...