Bone marrow stromal cells reduce low-dose cytarabine-induced differentiation of acute myeloid leukemia

• المؤلفون الرئيسيون: Tomislav Smoljo (مؤلف), Barbara Tomic (مؤلف), Hrvoje Lalic (مؤلف), Vilma Dembitz (مؤلف), Josip Batinic (مؤلف), Antonio Bedalov (مؤلف), Dora Visnjic (مؤلف)
• التنسيق: كتاب
• منشور في: Frontiers Media S.A., 2023-10-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Low-dose cytarabine (LDAC) is a standard therapy for elderly acute myeloid leukemia (AML) patients unfit for intensive chemotherapy. While high doses of cytarabine induce cytotoxicity, the precise mechanism of action of LDAC in AML remains elusive. In vitro studies have demonstrated LDAC-induced dif...