Targeting Cytokine Release Through the Differential Modulation of Nrf2 and NF-κB Pathways by Electrophilic/Non-Electrophilic Compounds

• Main Authors: Francesca Fagiani (Author), Michele Catanzaro (Author), Erica Buoso (Author), Filippo Basagni (Author), Daniele Di Marino (Author), Stefano Raniolo (Author), Marialaura Amadio (Author), Eric H. Frost (Author), Emanuela Corsini (Author), Marco Racchi (Author), Tamas Fulop (Author), Stefano Govoni (Author), Michela Rosini (Author), Cristina Lanni (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The transcription factor Nrf2 coordinates a multifaceted response to various forms of stress and to inflammatory processes, maintaining a homeostatic intracellular environment. Nrf2 anti-inflammatory activity has been related to the crosstalk with the transcription factor NF-κB, a pivotal mediator o...