Brozopine ameliorates cognitive impairment via upregulating Nrf2, antioxidation and anti-inflammation activities

• Main Authors: Zhenzhen Fu (Author), Xuening Wang (Author), Yanan Fan (Author), Dong Shang (Author), Jiahua Zhang (Author), Tingting Xiao (Author), Jiajun Guo (Author), Yi Wang (Author), Zhiyu Wang (Author), Zixin Zhang (Author), Qingran Jia (Author), Jinpeng Zhu (Author), Alireza Behrouznam Jahromi (Author), Yinuo Meng (Author), Na Gao (Author), Junbiao Chang (Author), Yuan Gao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxidative stress and inflammation are crucial factors contributing to the occurrence and development of vascular dementia (VD). In a previous study, we demonstrated that brozopine (BZP) is an anti-ischemic drug. In this study, a model of VD in rats with modified permanent bilateral common carotid ar...