Design, synthesis, and biological evaluation of thiazole/thiadiazole carboxamide scaffold-based derivatives as potential c-Met kinase inhibitors for cancer treatment

• Main Authors: Xiang Nan (Author), Qiu-Xu Wang (Author), Shao-Jun Xing (Author), Zhi-Gang Liang (Author)
• Format: Bog
• Udgivet: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Fag: article
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As part of our continuous efforts to discover novel c-Met inhibitors as antitumor agents, four series of thiazole/thiadiazole carboxamide-derived analogues were designed, synthesised, and evaluated for the in vitro activity against c-Met and four human cancer cell lines. After five cycles of optimis...