Acute and long-term outcomes in a Drosophila melanogaster model of classic galactosemia occur independently of galactose-1-phosphate accumulation

• Main Authors: Jennifer M. I. Daenzer (Author), Patricia P. Jumbo-Lucioni (Author), Marquise L. Hopson (Author), Kerry R. Garza (Author), Emily L. Ryan (Author), Judith L. Fridovich-Keil (Author)
• Format: Book
• Published: The Company of Biologists, 2016-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Classic galactosemia (CG) is a potentially lethal inborn error of metabolism that results from the profound loss of galactose-1-phosphate uridylyltransferase (GALT), the second enzyme in the Leloir pathway of galactose metabolism. Neonatal detection and dietary restriction of galactose minimizes or...