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A novel inhibitor of N6-methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities

N6-methyladenosine (m6A) modification is critical for mRNA splicing, nuclear export, stability and translation. Fat mass and obesity-associated protein (FTO), the first identified m6A demethylase, is critical for cancer progression. Herein, we developed small-molecule inhibitors of FTO by virtual sc...

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Main Authors: Guoyou Xie (Author), Xu-Nian Wu (Author), Yuyi Ling (Author), Yalan Rui (Author), Deyan Wu (Author), Jiawang Zhou (Author), Jiexin Li (Author), Shuibin Lin (Author), Qin Peng (Author), Zigang Li (Author), Hongsheng Wang (Author), Hai-Bin Luo (Author)
Format: Book
Published: Elsevier, 2022-02-01T00:00:00Z.
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