Pharmacological and Epigenetic Regulators of NLRP3 Inflammasome Activation in Alzheimer's Disease

• Main Authors: Francesca La Rosa (Author), Roberta Mancuso (Author), Simone Agostini (Author), Federica Piancone (Author), Ivana Marventano (Author), Marina Saresella (Author), Ambra Hernis (Author), Chiara Fenoglio (Author), Daniela Galimberti (Author), Elio Scarpini (Author), Mario Clerici (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Activation of the NLRP3 inflammasome complex results in the production of IL-18, Caspase-1 and IL-1β. These cytokines have a beneficial role in promoting inflammation, but an excessive activation of the inflammasome and the consequent constitutive inflammatory status is a negative factor in human pa...