Pharmacological and Epigenetic Regulators of NLRP3 Inflammasome Activation in Alzheimer's Disease

• मुख्य लेखकों: Francesca La Rosa (लेखक), Roberta Mancuso (लेखक), Simone Agostini (लेखक), Federica Piancone (लेखक), Ivana Marventano (लेखक), Marina Saresella (लेखक), Ambra Hernis (लेखक), Chiara Fenoglio (लेखक), Daniela Galimberti (लेखक), Elio Scarpini (लेखक), Mario Clerici (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2021-11-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Activation of the NLRP3 inflammasome complex results in the production of IL-18, Caspase-1 and IL-1β. These cytokines have a beneficial role in promoting inflammation, but an excessive activation of the inflammasome and the consequent constitutive inflammatory status is a negative factor in human pa...