Relationship between CYP3A5 Polymorphism and Tacrolimus Blood Concentration Changes in Allogeneic Hematopoietic Stem Cell Transplant Recipients during Continuous Infusion

• Main Authors: Naoki Yoshikawa (Author), Hidemi Takeshima (Author), Masaaki Sekine (Author), Keiichi Akizuki (Author), Tomonori Hidaka (Author), Kazuya Shimoda (Author), Ryuji Ikeda (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A polymorphism in the gene encoding the metabolic enzyme cytochrome P450 family 3 subfamily A member 5 (CYP3A5) is a particularly influential factor in the use of tacrolimus in Japanese patients. Those who are homozygotic for the <i>*3</i> mutation lack CYP3A5 activity, which results in...