An iRGD‐conjugated photothermal therapy‐responsive gold nanoparticle system carrying siCDK7 induces necroptosis and immunotherapeutic responses in lung adenocarcinoma

• Main Authors: Rui Cai (Author), Meng Wang (Author), Meiyuan Liu (Author), Xiongjie Zhu (Author), Longbao Feng (Author), Zhongjian Yu (Author), Xia Yang (Author), Zhiwu Zhang (Author), Huili Guo (Author), Rui Guo (Author), Yanfang Zheng (Author)
• Format: Book
• Published: Wiley, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Although immunotherapy has improved the clinical treatment of lung adenocarcinoma (LUAD), many tumors have poor responses to immunotherapy. In this study, we confirmed that high expression of Cyclin‐Dependent Kinase 7 (CDK7) promoted an immunosuppressive macrophage phenotype and macrophage...