Primary resistance to first-generation EGFR-TKIs induced by MDM2 amplification in NSCLC

• Principais autores: Dantong Sun (Autor), Yan Zhu (Autor), Jingjuan Zhu (Autor), Junyan Tao (Autor), Xiaojuan Wei (Autor), Yang Wo (Autor), Helei Hou (Autor)
• Formato: Livro
• Publicado em: BMC, 2020-07-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract Introduction Targeted therapy for NSCLC is rapidly evolving. EGFR-TKIs benefit NSCLC patients with sensitive EGFR mutations and significantly prolong survival. However, 20-30% of patients demonstrate primary resistance to EGFR-TKIs, which leads to the failure of EGFR-TKI treatment. The mech...