Primary resistance to first-generation EGFR-TKIs induced by MDM2 amplification in NSCLC

• Main Authors: Dantong Sun (Author), Yan Zhu (Author), Jingjuan Zhu (Author), Junyan Tao (Author), Xiaojuan Wei (Author), Yang Wo (Author), Helei Hou (Author)
• Format: Book
• Published: BMC, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Introduction Targeted therapy for NSCLC is rapidly evolving. EGFR-TKIs benefit NSCLC patients with sensitive EGFR mutations and significantly prolong survival. However, 20-30% of patients demonstrate primary resistance to EGFR-TKIs, which leads to the failure of EGFR-TKI treatment. The mech...