Primary resistance to first-generation EGFR-TKIs induced by MDM2 amplification in NSCLC
Abstract Introduction Targeted therapy for NSCLC is rapidly evolving. EGFR-TKIs benefit NSCLC patients with sensitive EGFR mutations and significantly prolong survival. However, 20-30% of patients demonstrate primary resistance to EGFR-TKIs, which leads to the failure of EGFR-TKI treatment. The mech...
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2020-07-01T00:00:00Z.
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