Identification of anisomycin, prodigiosin and obatoclax as compounds with broad-spectrum anti-parasitic activity.

• Main Authors: Gretchen Ehrenkaufer (Author), Pengyang Li (Author), Erin E Stebbins (Author), Monica M Kangussu-Marcolino (Author), Anjan Debnath (Author), Corin V White (Author), Matthew S Moser (Author), Joseph DeRisi (Author), Jolyn Gisselberg (Author), Ellen Yeh (Author), Steven C Wang (Author), Ana Hervella Company (Author), Ludovica Monti (Author), Conor R Caffrey (Author), Christopher D Huston (Author), Bo Wang (Author), Upinder Singh (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Parasitic infections are a major source of human suffering, mortality, and economic loss, but drug development for these diseases has been stymied by the significant expense involved in bringing a drug though clinical trials and to market. Identification of single compounds active against multiple p...