HERC1 Ubiquitin Ligase Is Required for Hippocampal Learning and Memory

• Main Authors: Eva M. Pérez-Villegas (Author), Mikel Pérez-Rodríguez (Author), José V. Negrete-Díaz (Author), Rocío Ruiz (Author), Jose Luis Rosa (Author), Guillermo Alvarez de Toledo (Author), Antonio Rodríguez-Moreno (Author), José A. Armengol (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mutations in the human HERC1 E3 ubiquitin ligase protein develop intellectual disability. The tambaleante (tbl) mouse carries a HERC1 mutation characterized by cerebellar ataxia due of adult cerebellar Purkinje cells death by extensive autophagy. Our previous studies demonstrated that both the neuro...