1,2,4-Triazole-based anticonvulsant agents with additional ROS scavenging activity are effective in a model of pharmacoresistant epilepsy

• Main Authors: Barbara Kaproń (Author), Robert Czarnomysy (Author), Mariusz Wysokiński (Author), Rudolf Andrys (Author), Kamil Musilek (Author), Andrea Angeli (Author), Claudiu T. Supuran (Author), Tomasz Plech (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

There are numerous studies supporting the contribution of oxidative stress to the pathogenesis of epilepsy. Prolonged oxidative stress is associated with the overexpression of ATP-binding cassette transporters, which results in antiepileptic drugs resistance. During our studies, three 1,2,4-triazole...