1,2,4-Triazole-based anticonvulsant agents with additional ROS scavenging activity are effective in a model of pharmacoresistant epilepsy

• Κύριοι συγγραφείς: Barbara Kaproń (Συγγραφέας), Robert Czarnomysy (Συγγραφέας), Mariusz Wysokiński (Συγγραφέας), Rudolf Andrys (Συγγραφέας), Kamil Musilek (Συγγραφέας), Andrea Angeli (Συγγραφέας), Claudiu T. Supuran (Συγγραφέας), Tomasz Plech (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

There are numerous studies supporting the contribution of oxidative stress to the pathogenesis of epilepsy. Prolonged oxidative stress is associated with the overexpression of ATP-binding cassette transporters, which results in antiepileptic drugs resistance. During our studies, three 1,2,4-triazole...