RANGE: Gene Transfer of Reversibly Controlled Polycistronic Genes

• Main Authors: Yiwei Chen (Author), Liji Cao (Author), Chonglin Luo (Author), Désirée AW Ditzel (Author), Jörg Peter (Author), Rolf Sprengel (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We developed a single vector recombinant adeno-associated viral (rAAV) expression system for spatial and reversible control of polycistronic gene expression. Our approach (i) integrates the advantages of the tetracycline (Tet)-controlled transcriptional silencer tTSKid and the self-cleaving 2A pepti...