Blocking the IGF2BP1-promoted glucose metabolism of colon cancer cells via direct de-stabilizing mRNA of the LDHA enhances anticancer effects

• المؤلفون الرئيسيون: Xiang-liang Zhang (مؤلف), Ke-jun Li (مؤلف), Jin-xin Feng (مؤلف), Gao-jie Liu (مؤلف), Yan-lin Feng (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2021-03-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Colorectal cancer (CRC) is a commonly diagnosed cancer with poor prognosis and high mortality rate. Hyperthermia (HT) is an adjunctive therapy to enhance the antitumor effects of traditional chemo- or radio- therapy. Here, we report that a cluster of essential regulator genes and speed-limit enzymes...