5-(Sulfamoyl)thien-2-yl 1,3-oxazole inhibitors of carbonic anhydrase II with hydrophilic periphery

• Main Authors: Stanislav Kalinin (Author), Alexander Kovalenko (Author), Annika Valtari (Author), Alessio Nocentini (Author), Maxim Gureev (Author), Arto Urtti (Author), Mikhail Korsakov (Author), Claudiu T. Supuran (Author), Mikhail Krasavin (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hydrophilic derivatives of an earlier described series of carbonic anhydrase inhibitors have been designed, prepared and profiled against a panel of carbonic anhydrase isoforms, including the glaucoma-related hCA II. For all hydrophilic derivatives, computational prediction of intraocular permeabili...