Quantification of 1D, a novel derivative of curcumin with potential antitumor activity, in rat plasma by liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study in rats

• Main Authors: Jialin Sun (Author), Tao Jiang (Author), Wen Xu (Author), Zhangying Feng (Author), Xianghua Quan (Author), Ping Leng (Author), Wei Sun (Author), Jun Zhao (Author), Fanbo Jing (Author), Jing Li (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Context: 1 D is a novel derivative of curcumin and shows very promising antitumor activities in various cancer cell lines. Objective: To characterize its preclinical pharmacokinetic profiles, a novel liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the...