Tubular epithelial cell-derived extracellular vesicles induce macrophage glycolysis by stabilizing HIF-1α in diabetic kidney disease

• Main Authors: Yijie Jia (Author), Jiaqi Chen (Author), Zhikang Zheng (Author), Yuan Tao (Author), Shuting Zhang (Author), Meina Zou (Author), Yanlin Yang (Author), Meng Xue (Author), Fang Hu (Author), Yang Li (Author), Qian Zhang (Author), Yaoming Xue (Author), Zongji Zheng (Author)
• Format: Book
• Published: BMC, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Albuminuria is a hallmark of diabetic kidney disease (DKD) that promotes its progression, leading to renal fibrosis. Renal macrophage function is complex and influenced by macrophage metabolic status. However, the metabolic state of diabetic renal macrophages and the impact of al...