Dammarane triterpenes targeting α-synuclein: biological activity and evaluation of binding sites by molecular docking

• Main Authors: Alberto Cornejo (Author), Julio Caballero (Author), Mario Simirgiotis (Author), Vanessa Torres (Author), Luisa Sánchez (Author), Nicolás Díaz (Author), Marcela Guimaraes (Author), Marcos Hernández (Author), Carlos Areche (Author), Sergio Alfaro (Author), Leonardo Caballero (Author), Francisco Melo (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Parkinson's disease (PD) is a neurodegenerative disorder that affects adult people whose treatment is palliative. Thus, we decided to test three dammarane triterpenes 1, 1a, 1b, and we determined that 1 and 1a inhibit β-aggregation through thioflavine T rather than 1b. Since compound 1 was most...