Dammarane triterpenes targeting α-synuclein: biological activity and evaluation of binding sites by molecular docking

• المؤلفون الرئيسيون: Alberto Cornejo (مؤلف), Julio Caballero (مؤلف), Mario Simirgiotis (مؤلف), Vanessa Torres (مؤلف), Luisa Sánchez (مؤلف), Nicolás Díaz (مؤلف), Marcela Guimaraes (مؤلف), Marcos Hernández (مؤلف), Carlos Areche (مؤلف), Sergio Alfaro (مؤلف), Leonardo Caballero (مؤلف), Francisco Melo (مؤلف)
• التنسيق: كتاب
• منشور في: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Parkinson's disease (PD) is a neurodegenerative disorder that affects adult people whose treatment is palliative. Thus, we decided to test three dammarane triterpenes 1, 1a, 1b, and we determined that 1 and 1a inhibit β-aggregation through thioflavine T rather than 1b. Since compound 1 was most...