INFLUENCE OF POMEGRANATE JUICE ON THE CYP3A4-MEDIATED METABOLISM AND P-GLYCOPROTEIN MEDIATED TRANSPORT OF SAQUINAVIR IN VIVO AND EX VIVO MODELS

• Main Authors: Sridhar Vemulapalli (Author), Surya Sandeep Mullapudi (Author), Ravindrababu Pingili (Author), Ramya Kothapalli (Author), Sivaramakrishna Kondru (Author), Naveenbabu Kilaru (Author)
• Format: Book
• Published: Universitas Gadjah Mada, 2016-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp) play an important role in the first pass metabolism thereby limits the oral bioavailability of many clinically important and frequently prescribed drugs. The absolute oral bioavailability of saquinavir is very low (i. e. 4%) due to its extensive...