A multidimensional metabolomics workflow to image biodistribution and evaluate pharmacodynamics in adult zebrafish

• 主要な著者: Madelyn M. Jackstadt (著者), Casey A. Chamberlain (著者), Steven R. Doonan (著者), Leah P. Shriver (著者), Gary J. Patti (著者)
• フォーマット: 図書
• 出版事項: The Company of Biologists, 2022-08-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

An integrated evaluation of the tissue distribution and pharmacodynamic properties of a therapeutic is essential for successful translation to the clinic. To date, however, cost-effective methods to measure these parameters at the systems level in model organisms are lacking. Here, we introduce a mu...