Blocking mTOR Signalling with Rapamycin Ameliorates Imiquimod-induced Psoriasis in Mice

• मुख्य लेखकों: Claudia Bürger (लेखक), Nitesh Shirsath (लेखक), Victoria Lang (लेखक), Sandra Diehl (लेखक), Roland Kaufmann (लेखक), Andreas Weigert (लेखक), Ying-ying Han (लेखक), Christian Ringel (लेखक), Peter Wolf (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Medical Journals Sweden, 2017-06-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The mTOR (mechanistic target of rapamycin) inhibitor rapamycin has long been known for its immune suppressive properties, but it has shown limited therapeutic success when given systemically to patients with psoriasis. Recent data have shown that the mTOR pathway is hyperactivated in lesional psoria...