Blocking mTOR Signalling with Rapamycin Ameliorates Imiquimod-induced Psoriasis in Mice

• Main Authors: Claudia Bürger (Author), Nitesh Shirsath (Author), Victoria Lang (Author), Sandra Diehl (Author), Roland Kaufmann (Author), Andreas Weigert (Author), Ying-ying Han (Author), Christian Ringel (Author), Peter Wolf (Author)
• Format: Book
• Published: Medical Journals Sweden, 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The mTOR (mechanistic target of rapamycin) inhibitor rapamycin has long been known for its immune suppressive properties, but it has shown limited therapeutic success when given systemically to patients with psoriasis. Recent data have shown that the mTOR pathway is hyperactivated in lesional psoria...