Effects of TPMT, NUDT15, and ITPA Genetic Variants on 6-Mercaptopurine Toxicity for Pediatric Patients With Acute Lymphoblastic Leukemia in Yunnan of China

• Main Authors: Xiaoyan Mao (Author), Runxiu Yin (Author), Gaoyuan Sun (Author), Yan Zhou (Author), Chunhui Yang (Author), Chunlian Fang (Author), Yuhong Wu (Author), Tingting Cui (Author), Li Liu (Author), Jiaxin Gan (Author), Xin Tian (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: 6-Mercaptopurine (6-MP) is the cornerstone of current antileukemia regimen and contributes greatly to improve the survival of pediatric acute lymphoblastic leukemia (ALL) patients. However, 6-MP dose-related toxicities limit its application. TPMT, NUDT15, and ITPA are pharmacogenetic mar...