Pristimerin inhibits thioredoxin reductase in the treatment of non-small cell lung cancer

• Main Authors: Yajun Chu (Author), Qianhe Xu (Author), Xiedong Zhou (Author), Qiuying Nie (Author), Xiaojun Yao (Author), Jianguo Fang (Author), Junmin Zhang (Author)
• Format: Book
• Published: Compuscript Ltd, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Elevated cellular oxidative stress is a common marker of cancer cell dysregulation caused by malignant transformation. Thioredoxin reductase (TrxR, encoded by TXNRD) is a crucial enzyme that regulates cellular oxidative stress and the survival of many types of cancer cells. Therefore, targeting TrxR...