OR2AT4 and OR1A2 counterregulate molecular pathophysiological processes of steroid-resistant inflammatory lung diseases in human alveolar macrophages

• Main Authors: Daniel Weidinger (Author), Kaschin Jamal Jameel (Author), Desiree Alisch (Author), Julian Jacobsen (Author), Paul Bürger (Author), Matthias Ruhe (Author), Faisal Yusuf (Author), Simon Rohde (Author), Klemens Störtkuhl (Author), Peter Kaufmann (Author), Juliane Kronsbein (Author), Marcus Peters (Author), Hanns Hatt (Author), Nikolaos Giannakis (Author), Jürgen Knobloch (Author)
• Format: Book
• Published: BMC, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Therapeutic options for steroid-resistant non-type 2 inflammation in obstructive lung diseases are lacking. Alveolar macrophages are central in the progression of these diseases by releasing proinflammatory cytokines, making them promising targets for new therapeutic approaches....