Ononin ameliorates inflammation and cartilage degradation in rat chondrocytes with IL-1β-induced osteoarthritis by downregulating the MAPK and NF-κB pathways

• Main Authors: Fang Xu (Author), Liang-Jun Zhao (Author), Ting Liao (Author), Zhao-Cong Li (Author), Lei-Lei Wang (Author), Pan-Yu Lin (Author), Rui Jiang (Author), Qing-Jun Wei (Author)
• Format: Book
• Published: BMC, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Osteoarthritis (OA) treatment aims to improve inflammation and delay cartilage degeneration. However, there is no effective strategy presently available. Ononin, a representative isoflavone glycoside component extracted from natural Chinese herbs, exerts anti-inflammatory and pro...