Modeling tuberculous meningitis in zebrafish using Mycobacterium marinum

• Main Authors: Lisanne M. van Leeuwen (Author), Martijn van der Kuip (Author), Sameh A. Youssef (Author), Alain de Bruin (Author), Wilbert Bitter (Author), A. Marceline van Furth (Author), Astrid M. van der Sar (Author)
• Format: Book
• Published: The Company of Biologists, 2014-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tuberculous meningitis (TBM) is one of the most severe extrapulmonary manifestations of tuberculosis, with a high morbidity and mortality. Characteristic pathological features of TBM are Rich foci, i.e. brain- and spinal-cord-specific granulomas formed after hematogenous spread of pulmonary tubercul...