Yokukansan Inhibits the Development of Morphine Tolerance by Regulating Presynaptic Proteins in DRG Neurons

• Egile Nagusiak: Yusuke Ohashi (Egilea), Fatma Zahra Sakhri (Egilea), Hideshi Ikemoto (Egilea), Takayuki Okumo (Egilea), Naoki Adachi (Egilea), Masataka Sunagawa (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Opioids, such as morphine, are used in clinical settings for the management of acute and chronic pain. However, long-term use of morphine leads to antinociceptive tolerance and hypersensitivity. The cellular and molecular mechanisms of morphine tolerance seem to be quite complex, with suggestions in...