Progress and Innovative Combination Therapies in Trop-2-Targeted ADCs

• Main Authors: Yizhi Jiang (Author), Haiting Zhou (Author), Junxia Liu (Author), Wentao Ha (Author), Xiaohui Xia (Author), Jiahao Li (Author), Tengfei Chao (Author), Huihua Xiong (Author)
• Format: Book
• Published: MDPI AG, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Precise targeting has become the main direction of anti-cancer drug development. Trophoblast cell surface antigen 2 (Trop-2) is highly expressed in different solid tumors but rarely in normal tissues, rendering it an attractive target. Trop-2-targeted antibody-drug conjugates (ADCs) have displayed p...