Pharmacodynamics and Pharmacokinetics of HSK3486, a Novel 2,6-Disubstituted Phenol Derivative as a General Anesthetic

• Main Authors: Juan Liao (Author), Meiting Li (Author), Chaoli Huang (Author), Yan Yu (Author), Yashu Chen (Author), Jiaqi Gan (Author), Jie Xiao (Author), Guilin Xiang (Author), Xizhi Ding (Author), Rong Jiang (Author), Peng Li (Author), Mengchang Yang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: The purpose of this study was to characterize the novel sedative/hypnotic agent HSK3486, a 2,6-disubstituted alkylphenol analogue.Methods: The mechanism of action of HSK3486 was studied in competitive binding assays and whole-cell patch clamp assays. HSK3486 was administered by bolus int...