Moderate voluntary exercise attenuates the metabolic syndrome in melanocortin-4 receptor-deficient rats showing central dopaminergic dysregulation

• Main Authors: Silvana Obici (Author), I. Jack Magrisso (Author), Armen S. Ghazarian (Author), Alireza Shirazian (Author), Jonas R. Miller (Author), Christine M. Loyd (Author), Denovan P. Begg (Author), Kimberly A. Krawczewski Carhuatanta (Author), Michael K. Haas (Author), Jon F. Davis (Author), Stephen C. Woods (Author), Darleen A. Sandoval (Author), Randy J. Seeley (Author), Laurie J. Goodyear (Author), Emmanuel N. Pothos (Author), Joram D. Mul (Author)
• Format: Book
• Published: Elsevier, 2015-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Melanocortin-4 receptors (MC4Rs) are highly expressed by dopamine-secreting neurons of the mesolimbic tract, but their functional role has not been fully resolved. Voluntary wheel running (VWR) induces adaptations in the mesolimbic dopamine system and has a myriad of long-term beneficial...