Complete Dependence on CD4+ Cells in Late Asthmatic Response, but Limited Contribution of the Cells to Airway Remodeling in Sensitized Mice

• Main Authors: Takeshi Nabe (Author), Toyoko Morishita (Author), Kouki Matsuya (Author), Ayumu Ikedo (Author), Masanori Fujii (Author), Nobuaki Mizutani (Author), Shin Yoshino (Author)
• Format: Book
• Published: Elsevier, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: It is known that the late asthmatic response (LAR), a characteristic feature of asthma, is closely associated with CD4+ Th2 cell-mediated allergic inflammation. Airway remodeling is also a pathogenesis of asthma, but literature reporting roles of CD4+ cells in the remodeling is controvers...