Discovery of a New Chalcone-Trimethoxycinnamide Hybrid with Antimitotic Effect: Design, Synthesis, and Structure-Activity Relationship Studies

• Main Authors: Joana Moreira (Author), Patrícia M. A. Silva (Author), Matilde Barros (Author), Lucília Saraiva (Author), Madalena Pinto (Author), Hassan Bousbaa (Author), Honorina Cidade (Author)
• Format: Book
• Published: MDPI AG, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this work, the design and synthesis of a new chalcone-trimethoxycinnamide hybrid (<b>7</b>) based on the combination of subunits of two promising antiproliferative compounds (<b>CM-M345</b> (<b>1</b>) and <b>BP-M345</b> (<b>2</b>)), prev...