Targeting BMI-1-mediated epithelial-mesenchymal transition to inhibit colorectal cancer liver metastasis

• Main Authors: Zhiyao Xu (Author), Zhuha Zhou (Author), Jing Zhang (Author), Feichao Xuan (Author), Mengjing Fan (Author), Difan Zhou (Author), Zhenyu Liuyang (Author), Ximei Ma (Author), Yiyang Hong (Author), Yihong Wang (Author), Sherven Sharma (Author), Qinghua Dong (Author), Guanyu Wang (Author)
• Format: Book
• Published: Elsevier, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Liver is the most common metastatic site for colorectal cancer (CRC), there is no satisfied approach to treat CRC liver metastasis (CRCLM). Here, we investigated the role of a polycomb protein BMI-1 in CRCLM. Immunohistochemical analysis showed that BMI-1 expression in liver metastases was upregulat...