Targeting BMI-1-mediated epithelial-mesenchymal transition to inhibit colorectal cancer liver metastasis

• Главные авторы: Zhiyao Xu (Автор), Zhuha Zhou (Автор), Jing Zhang (Автор), Feichao Xuan (Автор), Mengjing Fan (Автор), Difan Zhou (Автор), Zhenyu Liuyang (Автор), Ximei Ma (Автор), Yiyang Hong (Автор), Yihong Wang (Автор), Sherven Sharma (Автор), Qinghua Dong (Автор), Guanyu Wang (Автор)
• Формат: ‌
• Опубликовано: Elsevier, 2021-05-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Liver is the most common metastatic site for colorectal cancer (CRC), there is no satisfied approach to treat CRC liver metastasis (CRCLM). Here, we investigated the role of a polycomb protein BMI-1 in CRCLM. Immunohistochemical analysis showed that BMI-1 expression in liver metastases was upregulat...