Janus kinase inhibitors suppress cancer cachexia‐associated anorexia and adipose wasting in mice

• Main Authors: Gurpreet K. Arora (Author), Arun Gupta (Author), Tong Guo (Author), Aakash Y. Gandhi (Author), Aaron Laine (Author), Dorothy L. Williams (Author), Chul Ahn (Author), Puneeth Iyengar (Author), Rodney E. Infante (Author)
• Format: Book
• Published: Wiley, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Cachexia, a syndrome of muscle atrophy, adipose loss, and anorexia, is associated with reduced survival in cancer patients. The colon adenocarcinoma C26c20 cell line secretes the cytokine leukaemia inhibitory factor (LIF), which induces cachexia. We characterized how LIF promotes...