Quinazolin-4-one derivatives lacking toxicity-producing attributes as glucokinase activators: design, synthesis, molecular docking, and in-silico ADMET prediction

• Main Authors: Saurabh C. Khadse (Author), Nikhil D. Amnerkar (Author), Manasi U. Dave (Author), Deepak K. Lokwani (Author), Ravindra R. Patil (Author), Vinod G. Ugale (Author), Nitin B. Charbe (Author), Vivekanand A. Chatpalliwar (Author)
• Format: Book
• Published: SpringerOpen, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background A small library of quinazolin-4-one clubbed thiazole acetates/acetamides lacking toxicity-producing functionalities was designed, synthesized, and evaluated for antidiabetic potential as glucokinase activators (GKA). Molecular docking studies were done in the allosteric site of t...