An adapted consensus protein design strategy for identifying globally optimal biotherapeutics

• Main Authors: Yanyun Liu (Author), Kenny Tsang (Author), Michelle Mays (Author), Gale Hansen (Author), Jeffrey Chiecko (Author), Maureen Crames (Author), Yangjie Wei (Author), Weijie Zhou (Author), Chase Fredrick (Author), James Hu (Author), Dongmei Liu (Author), Douglas Gebhard (Author), Zhong-Fu Huang (Author), Akshita Datar (Author), Anthony Kronkaitis (Author), Kristina Gueneva-Boucheva (Author), Daniel Seeliger (Author), Fei Han (Author), Saurabh Sen (Author), Srinath Kasturirangan (Author), Justin M. Scheer (Author), Andrew E. Nixon (Author), Tadas Panavas (Author), Michael S. Marlow (Author), Sandeep Kumar (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Biotherapeutic optimization, whether to improve general properties or to engineer specific attributes, is a time-consuming process with uncertain outcomes. Conversely, Consensus Protein Design has been shown to be a viable approach to enhance protein stability while retaining function. In adapting t...