Defining the target and the effect of imatinib on the filarial c-Abl homologue.

• Main Authors: Elise M O'Connell (Author), Olena Kamenyeva (Author), Sara Lustigman (Author), Aaron Bell (Author), Thomas B Nutman (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Previously we demonstrated the micro- and macrofilaricidal properties of imatinib in vitro. Here we use electron and multiphoton microscopy to define the target of imatinib in the adult and microfilarial stages of Brugia malayi and assess the effects of pharmacologically relevant levels of imatinib...