Repositioning Linagliptin for the Mitigation of Cadmium-Induced Testicular Dysfunction in Rats: Targeting HMGB1/TLR4/NLRP3 Axis and Autophagy

• Main Authors: Hany H. Arab (Author), Alzahraa A. Elhemiely (Author), Azza A. K. El-Sheikh (Author), Hana J. Al Khabbaz (Author), El-Shaimaa A. Arafa (Author), Ahmed M. Ashour (Author), Ahmed M. Kabel (Author), Ahmed H. Eid (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cadmium, a ubiquitous environmental toxicant, disrupts testicular function and fertility. The dipeptidyl peptidase-4 inhibitor linagliptin has shown pronounced anti-inflammatory and anti-apoptotic features; however, its effects against cadmium-evoked testicular impairment have not been examined. Her...