Evaluation of Pupillometry for CYP2D6 Phenotyping in Children Treated with Tramadol

• Main Authors: Frédérique Rodieux (Author), Flavia Storelli (Author), François Curtin (Author), Sergio Manzano (Author), Alain Gervaix (Author), Klara M. Posfay-Barbe (Author), Jules Desmeules (Author), Youssef Daali (Author), Caroline F. Samer (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Following the contraindication of codeine use in children, increasing use of tramadol has been observed in pain management protocols. However, tramadol's pharmacokinetics (PK) and pharmacodynamics are influenced by cytochrome P450 (CYP)2D6 activity, similarly to codeine. Previous studies in adu...