Pregnancy-Related Hormones Increase UGT1A1-Mediated Labetalol Metabolism in Human Hepatocytes

• Main Authors: Raju Khatri (Author), John K. Fallon (Author), Craig Sykes (Author), Natasha Kulick (Author), Rebecca J. B. Rementer (Author), Taryn A. Miner (Author), Amanda P. Schauer (Author), Angela D. M. Kashuba (Author), Kim A. Boggess (Author), Kim L. R. Brouwer (Author), Philip C. Smith (Author), Craig R. Lee (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pregnancy-related hormones (PRH) are recognized as important regulators of hepatic cytochrome P450 enzyme expression and function. However, the impact of PRH on the hepatic expression and function of uridine diphosphate glucuronosyltransferases (UGTs) remains unclear. Using primary human hepatocytes...