Binding of GS-461203 and Its Halogen Derivatives to HCV Genotype 2a RNA Polymerase Drug Resistance Mutants

• Hoofdauteurs: Muhammad Arba (Auteur), Setyanto Tri Wahyudi (Auteur), Muhammad Sulaiman Zubair (Auteur), Dylan Brunt (Auteur), Mursalin Singh (Auteur), Chun Wu (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2022-04-01T00:00:00Z.
• Onderwerpen: article
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Hepatitis C Virus (HCV) is reported to develop GS-461203 resistance because of multiple mutations within the RNA-dependent RNA Polymerase (RdRp) of HCV. The lack of a high-resolution structure of these RdRp mutants in complex with GS-461203 hinders efforts to understand the drug resistance. Here we...