Antidepressant-Like Effect of Venlafaxine Is Abolished in μ-Opioid Receptor-Knockout Mice

• Main Authors: Soichiro Ide (Author), Shunsuke Fujiwara (Author), Masayuki Fujiwara (Author), Ichiro Sora (Author), Kazutaka Ikeda (Author), Masabumi Minami (Author), George R. Uhl (Author), Kumatoshi Ishihara (Author)
• Format: Book
• Published: Elsevier, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although the opioid system is known to modulate depression-like behaviors, its role in the effects of antidepressants is not yet clear. We investigated the role of μ-opioid receptors (MOPs) in the effects of venlafaxine, a serotonin and norepinephrine reuptake inhibitor, in the forced swim test usin...